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Director: Antonio Nanci

Antonio Nanci is professor of cell biology and Director of the Laboratory for the Study of Calcified Tissues and Biomaterials at the Faculty of Dentistry of the Université de Montréal. In June 2007, he was elected Director of the Stomatogoly department of the Université de Montréal. The research focus of his group is the study of basic cell biological processes of normal and pathological calcified tissues, and in the integration of biomaterials. These investigations aim at developing novel therapeutic approaches and biomaterials. In the early 1980s, Nanci’s laboratory was the first to apply high-resolution colloidal gold immunolabeling for studying the distribution of matrix proteins in calcified tissues. This approach was subsequently used to investigate the composition of cement lines at natural bone interfaces and at the bone-biomaterial interface. These studies have led to a multidisciplinary team effort to develop a method to nanofabricate ‘coatings’ on implants with bioactive molecules to control and accelerate tissue repair. This molecular tissue engineering technology has been patented and recently has led to research collaboration with industry. Most recently, his group has been exploring gene transfer approaches for hard-tissue repair and was the first to successfully use lentiviral vectors for in vivo gene transfer in bone and teeth. Just recently, a grant was obtained to apply a novel functional genomics approach to identify the secretome of teeth and periodontal tissue.

Nanci’s laboratory has developed extensive expertise with various forms of structural imaging, and is one of the three poles of the Montreal Network for Materials, Structural and Molecular Imaging. It is frequently solicited by the biotech and pharmaceutical industry to help them characterize products and resolve production problems. Dr. Nanci  is also member of CDMC-CREATE, an innovative and interdisciplinary training program in the area of Cellular Dynamics of Macromolecular Complexes which aims to foster professional skills development in order to facilitate students transition to the workplace.

  • Education

(1982-1983) Post-doctoral fellow with Harold C. Slavkin in Craniofacial Developmental & Molecular Biology, University of Southern California, USA

(1978-1982) Doctor of Philosophy in Anatomy & Cell Biology, McGill Univeristy, Canada

(1976-1978) Master of Science in Pathology, Université de Montréal, Canada

(1973-1976) Bachelor of Science in Anatomy & Cell Biology, Université de Montréal, Canada

  • Member of Editorial Boards

(1) Journal of Histochemistry and Cytochemistry

(2) Journal of Electron Microscopy

(3) Anatomical Science International

(4) Journal of Dental Research